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This is your big night.

今兒晚上可是你的好日子。

It's been great talking to you.

和你談得真高興。

You'll send yourself to an early grave.

你這樣會未老先衰的。

Do you get the message?

明白我的意思沒有？

What does that mean in plain English?

你能不能用大白話解釋一下？

I must take issue with your over what you said at the meeting.

我要和你好好談?wù)勀阍跁险f的那些話。（take issue with someone: 對某人的觀點(diǎn)提出異議。）